The authors received no grants, equipment or funding for this study. Prognostic factors for all clear cell carcinomas of the vagina include stage at diagnosis, tumor size, and grade of the lesion, including architecture and nuclear grade, and appear to pertain equally to patients both DES-exposed and DES-unexposed. Read our ... with the disease severity being an independent predictor of poor outcome. 3a) and DSS (5-year DSS rates, 26.9% and 44.4%, respectively; P = 0.0034; Fig. Furthermore, there was no difference in the usage of antiplatelet drugs between the MPVlow and MPVhigh groups (P = 0.77). Preoperative neutrophil-to-lymphocyte ratio is a better prognostic serum biomarker than platelet-to-lymphocyte ratio in patients undergoing resection for nonmetastatic colorectal cancer. Survival curves according to MPV. These factors are acknowledged to be of importance for the course of RA [2]. For some diseases and conditions, such as non-Hodgkin lymphomas, the factors are scored to give a prognostic index. The AUC was highest for MPV among the four indicators (Fig. ‘the disease has a poor prognosis’. See Synonyms at predict. To foreshadow; portend: urban renewal that prognosticates a social and cultural … These are tumor-related indicators, whereas MPV is a patient-related indicator. Regarding the correlations between MPV and clinicopathological characteristics, the frequency of ly2/3 was significantly higher in patients with MPVlow than in those with MPVhigh (P = 0.005), while the frequency of v2/3 was significantly lower in patients with MPVlow than in those with MPVhigh (P = 0.011). Among patients who were DES-exposed, young age was also found to be a poor prognostic factor. Survival curves according to the combined analysis of MPV and serum CA19-9 level. Radiomics Analysis of Computed Tomography helps predict poor prognostic outcome in COVID-19 . The flat was in a poor state of repair..., The wine was poor. PubMed Google Scholar. More example sentences. In conclusion, our study indicated the usefulness of preoperative MPV as a prognostic indicator in patients with resected PC. The seventh edition of the General Rules for the Study of Pancreatic Cancer by the Japan Pancreas Society was used to evaluate lymphatic invasion, venous invasion, and perineural invasion [15]. little opportunity. Global cancer statistics, 2012. TY and HS participated in the design of the study, interpretation of data, analysis, and drafting the article. Mol Clin Oncol. TGF-β1 is an immunosuppressive cytokine and also an angiogenic factor. Sharma D, Brummel-Ziedins KE, Bouchard BA, Holmes CE. For cancers like lymphoma, many factors determine the outcome for each patient. 2014;157(2):382–94. Prognostic significance of preoperative mean platelet volume in resected non-small-cell lung cancer. Platelet activation and the spread of inflammation might thus explain why a decreased MPV was closely related to poor prognosis in patients with PC. We divided patients into MPVhigh (≥ 8.65; n = 40), MPVlow (< 8.65; n = 51), CA19-9high (≥ 66.3; n = 47), and CA19-9low (< 66.3; n = 44) groups based on the optimal cut-off values determined from receiver operating characteristic curve analysis. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Beyond that it can mean anything from permanent health damage to imminent death. Third, the detailed mechanisms related to the poor prognosis in patients with MPVlow remain unclear, and further investigations are urgently required to elucidate these. We first compared the AUC values of the ROC curves for platelet-related indicators (platelet count, MPV, PDW) and CA19-9 in relation to OS. 1. 2002;9(3):287–91. The term prognosis refers to making an educated guess about the expected outcome of any kind of health treatment, including mental health, in essence making a prediction of the process an individual may have to go through in order to heal, and the extent of healing expected to take place. Google Scholar. Find another word for prognosis. ...a piss-poor comedy directed by John Landis. The people in a poor country or area have very little money and few possessions. A dirt-poor person or place is extremely poor. PubMed Central  Gasparyan et al. 16 synonyms of prognosis from the Merriam-Webster Thesaurus, plus 13 related words, definitions, and antonyms. Second, the number of patients was relatively small, and a larger trial is required to confirm our results. Other serum markers are therefore required to predict the prognosis of PC patients more precisely than using CA19-9 alone. He was a poor actor..., Hospitals are poor at collecting information. PubMed  Learn more. During the first week, the evening meetings were poorly attended... You use poor to describe someone who is not very skilful in a particular activity. 2007;33(3):266–70. A total of 91 PC patients who underwent pancreatectomy were included in this study. Int J Gynecol Cancer. If you describe something as poor, you mean that it is of a low quality or standard or that it is in bad condition. Watercolour still seems somehow to be the poor relation of oil painting. You want to reject this entry: please give us your comments (bad translation/definition, duplicate entries...), English Portuguese translation in context, Free: Learn English, French and other languages, Reverso Documents: translate your documents online, Learn English watching your favourite videos, All English simple definitions from our dictionary. CAS  PDGF also inhibited the cell-killing effects of natural killer cells [18]. prognosis Is Not Just a Medical Term We previously reported the NLR as a poor prognostic marker in bladder cancer, upper-urothelial carcinoma, adrenocortical carcinoma, penile … Survival curves according to serum CA19-9 level. P < 0.05 was considered significant. outside chance. See more. MPV and serum carbohydrate antigen 19-9 (CA19-9) were measured within 1 week before surgery. Karpatkin S, Pearlstein E. Role of platelets in tumor cell metastases. 2020;219(1):93–8. PubMed  M. a doctor ’s opinion of how an illness or disease will develop → diagnosis good/poor prognosis Doctors said Blake’s long … If you describe one thing as a poor relationof another, you mean that it is similar to or part of the other thing, but is considered to be inferior to it. First, its retrospective design was associated with some bias. poor bet. Anticancer Res. 8th ed. Receiver operating characteristic (ROC) curve analysis was used to determine the Youden index and area under the curve (AUC). a MPV, b platelet count, c PDW, and d CA19-9. Google Scholar. Qingxia Wu 1*, Shuo Wang 2*, Liang Li 3*, Qingxia Wu 4, Wei Qian 5, Yahua Hu 6, Li Li 7, Xuezhi Zhou 8, He Ma 1 , Hongjun Li 7 , Meiyun Wang 4 , Xiaoming Qiu 6 , Yunfei Zha 3 , Jie Tian 1,2,8,9 . Platelet-derived endothelial cell growth factor. Cell. Enrich your vocabulary with the English Definition dictionary The patients were then divided into groups A (MPVhigh and CA19-9low), B (MPVhigh and CA19-9high), C (MPVlow and CA19-9low), and D (MPVlow and CA19-9high), with 5-year OS rates of 73.2%, 40.4%, 25.8%, and 10.3%, respectively (P = 0.0002), and 5-year DSS rates of 80.8%, 44.9%, 27.3%, and 16.4%, respectively (P = 0.0003). "When we focus too much on specific prognostic factors, we lose sight of the bigger picture." 1 The likely course of a medical condition. How to use prognosis in a sentence. We next divided the patients into CA19-9high (≥ 66.3; n = 47) and CA19-9low (< 66.3; n = 44) groups according to the optimal cut-off value determined by ROC curve analysis. Mean platelet volume (MPV) is a commonly used index of platelet size that has recently attracted attention as a novel prognostic indicator. a Overall survival. Refaai MA, Phipps RP, Spinelli SL, Blumberg N. Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes. » IKZF1plus Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell ... -free survival of 53 ± 6% compared with 79 ± 5% in patients with IKZF1 deletion who did not fulfill the IKZF1plus definition and 87 ± 1% in patients who lacked an IKZF1 deletion ( P ≤ .001). New Jersey: Wiley-Blackwell; 2017. 2a), while the 5-year DSS rates were 20.5% and 62.2% in the MPVlow and MPVhigh groups, respectively (P = 0.0031; Fig. 2012;15(2):265–73. Translation English Cobuild Collins Dictionary, Collaborative Dictionary     English Cobuild, [US];[informal] I shouldn’t have bought that used car, it’s way too janky.   Prognostic Factors in Lymphoma . Gerenal rules for the study of pancreatic cancer. Thromb Res. Furthermore, thrombocytosis is related to a poor prognosis in various cancers [22,23,24]. Before making recommendations about her patients' care, Dr. Intile focuses on remembering that every animal is a uniquely created organism and that many factors need to be weighed. We conducted this study to assess the prognostic value of MPV in patients with PC. Classification based on MPV and CA19-9 might be useful for predicting long-term outcomes in patients with PC. Matsumoto T, Okabayashi T, Sui K, Morita S, Iwata J, Shimada Y. Preoperative neutrophili-to-lymphocyte ratio is useful for stratifying the prognosis of tumor markers-negative pancreatic cancer patients. Prognosis definition: A prognosis is an estimate of the future of someone or something, especially about... | Meaning, pronunciation, translations and examples Patients were then divided into MPVhigh (≥ 8.65; n = 40) and MPVlow (< 8.65; n = 51) groups based on the optimal cut-off value from ROC curve analysis. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. There were 51 females and 29 males with a mean age of 29.9 years (11 to 78). Asian Pac J Cancer Prevent APJCP. poor lookout. Statistical analyses were carried out using Stat View (Abacus Concepts, Inc., Berkeley, CA, USA) and GraphPad Prism (GraphPad Software, Inc., La Jolla, CA, USA) software. b Disease-specific survival. 2010;140(6):883–99. Platelets in tumor progression: a host factor that offers multiple potential targets in the treatment of cancer. Furthermore, MPV was an independent prognostic indicator of DSS, together with lymph node metastasis, vascular invasion, residual tumor, adjuvant chemotherapy, and CA19-9 (Table 2). Furthermore, our results found no significant correlation between MPV and these tumor markers, indicating the usefulness of MPV as a prognostic indicator regardless of tumor-related prognostic indicators. Although chemotherapy had the potential to affect MPV, there was no significant relationship between neoadjuvant chemotherapy and MPV (P = 0.77; Table 1). 2016;7(49):81849–61. Ann Surg Oncol. The 5-year OS rate was significantly lower in the MPVlow compared with the MPVhigh group (16.9% vs. 56.3%; P = 0.0038; Fig. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Ann Intern Med. Large tumor, late staging, presence of cancer cells in multiple distant lymph nodes, and observation of metastasis often associate with poor prognosis. Hiroaki Saito. 2011;17(1):47–58. 2016;17(9):4433–7. cates 1. BMC Surg 21, 8 (2021). This study was approved by Certified Review Board, Tottori University Hospital and the requirement for informed consent was waived. 2014;229(8):1005–15. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Traditional prognostic markers in oncology include tumor size, staging, lymph node spreading status, and metastasis. little chance. Poor Prognosis Meaning in Hindi is . 2015;3(1):197–201. Platelets enhance the penetration of cancer cells through the blood vessel endothelial cell barrier, and prevent their clearance from the circulatory system by the immune cells [16]. PubMed  If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. However, approximately 10% of Japanese patients have a Lewis blood group-negative phenotype and show false-negative findings [12, 13], indicating that CA19-9 alone is not enough to precisely predict the prognosis of PC patients. All rights reserved. Prognostic scoring is also used for cancer outcome predictions. 2015;65(2):87–108. Explore Urdupoint dictionary to find out more meanings, definitions, synonyms and antonyms of the word Poor Prognosis. prog‧no‧sis /prɒɡˈnəʊsɪs $ prɑːɡˈnoʊ-/ noun (plural prognoses /-siːz/) [ countable] 1. Am J Surg. A Manchester score is an indicator of prognosis for small-cell lung cancer. Angiogenesis. CAS  Ikeda M, Furukawa H, Imamura H, Shimizu J, Ishida H, Masutani S, Tatsuta M, Satomi T. Poor prognosis associated with thrombocytosis in patients with gastric cancer. These results indicate that decreased MPV reflects the activation of platelets and the spread of inflammation in PC patients. statement and However, the prognostic significance of platelet count in the current study was low, indicating the possibility that increased platelet count does not always reflect an increased number of activated platelets. 4b). Multivariate analysis identified MPV as an independent prognostic indicator of OS, together with lymph node metastasis, lymphatic invasion, residual tumor, adjuvant chemotherapy, and CA19-9 (Table 2). Search poor prognosis and thousands of other words in English Cobuild dictionary from Reverso. You use poor to express your sympathy for someone. These observations suggest the possible usefulness of platelet indices as a prognostic indicator in cancer patients, including patients with PC. Data obtained from routine blood examinations meets these criteria. 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In English Cobuild dictionary from Reverso Review Board, Tottori University Hospital and the for. The aim of this study was approved by Certified Review Board, University... Choice of therapy in these patients is limited to foreshadow ; portend: urban renewal that prognosticates a and.