Fipronil 0.25 % w/v ... (flea allergy dermatitis) and lice in Dogs and Cats. Each card contains 3 or 6 pipettes. It is also used for other parasites such as chiggers, sarcoptic mange, cheyletiellosis, and otoacariasis. CAUTION. Beaphar FIPROtec® Spot-On is a veterinary strength medicine to kill fleas on cats and dogs within 24 hours and ticks within 48 hours. Il appartient à une famille chimique des phénylpyrazoles. Cutaneous spray, solution Fipronil should not be used in animals with known hypersensitivity or allergy to the drug. If your dog’s weight is in between 2 different weight ranges, use the box with the lower amount, or round down, to avoid overmedicating. Dogs 89-132 pounds - 4.0ml 2.7ml for 90lbs 4.0 for 133lbs. Fipronil (FIP) is a widely used ectoparasiticide in veterinary medicine available for topical administration; however, its use may cause damage to the owners and the environment. Mange . The rest of the fipronil was eliminated in the feces and urine. 2.94%. Fleas are all-too-common visitors to both cats and dogs. Depending on the length of the hair: The 250 mL pack size allows a 20 kg dog to be treated 2 to 4 times. Frontline Plus has the same % Fipronil for dogs AND cats, but LESS Methoprene for cats than dogs, so how is LESS going to hurt cats. Each unit dose (dual cavity pipette) delivers: CERTIFECT spot-on solution . Fipronil-based Effipro is also practical and affordable. fipronil dose for dogs, cats, and cattle Dosing recommendations for antiparasitics depend on national regulations. However, if your dog weighs more than 132 pounds, you’ll need to combine products to get the correct dosage. Please continue reading to learn how to adjust the dosage … Fipronil spray may be used on dogs or cats, but it is important you apply only as directed to prevent overdosing. In addition to flea and tick control, fipronil may be used to control chewing lice and to treat Cheyletiellosis. Fipronil is a broad-spectrum insecticide that belongs to the phenylpyrazole chemical family. Topical spray containing 0.25% fipronil applied to dogs at 1x, 3x and 5x recommended dose for a total of 6 applications each 28 days apart (DOG CLI 138). Acute Toxicity and Tolerance of Fipronil. It is currently marketed for veterinary use on dogs and cats to control fleas and ticks. Fipronil's effects take about 24 hours to begin and last about 30 days. See packaging for complete product details. For use only on dogs 8 weeks of age or older. No adverse effects were observed in target animal safety studies in 2 month-old puppies, growing dogs and dogs weighing about 2 kg treated with the therapeutic dose on five consecutive days. 1.07 ; 67 . Frontline dosage for dogs Frontline comes in ready-measured applications. Some dogs have a hypersensitivity to fipronil, so it is important to avoid Frontline if your dog is sensitive to these products. Mean drug dosage for all dogs was approximately 2 mg/kg body weight. Skip to main content.us. The dose of fipronil is based on the weight of the dog and pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds) and 4 ml (for dogs 89 to 132 pounds). The recommended minimum dose is 6.7 mg/kg bodyweight for fipronil, 6 mg/kg for (S)-methoprene and 8 mg/kg for amitraz. For use on dogs and puppies 8 weeks of age or older and weighing 4 lbs or greater. 0.2-3mg/kg. Note that dogs at the lower end of the weight ranges get twice this much, or even more for very small dogs. Fipronil disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride (GluCl) channels. 1 ml contains. 87.28%. Contraindictions, Warnings etc Contrary to many myths, they are equally at home in a clean house as a dirty one so you needn't be embarrassed to ask for help with controlling them. The box will show what size dogs that particular formulation is suitable and effective for. The topical spray is dosed for dogs and cats at 1.5 to 3 ml per pound of body weight. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance. topical . The spray gun sprays 1.5 mL per spray. One pipette is applied topically every 30 days. Animals with long hair need the higher dose. Fipronil spot-on is sold as separate canine and feline formulas, with the specific dosage based on the animal’s body weight. SC . Concerns About Fipronil. The risk of adverse effects may increase in cases of overdose. Cats benefit from 5 weeks flea protection and 2 weeks tick protection. 7.5 to 15 mg of fipronil per kg of body weight), depending on the length of the hair. Each trigger spray of the 250 ml bottle is 1.5 ml. Effipro will cover dogs against fleas for 8 weeks, and against ticks for 4 weeks. FRONTLINE® PLUS FOR DOGSprovides fast, effective and convenient treatment and control of fleas, ticks and chewing lice for dogs and puppies. While generally safe and effective when prescribed by a veterinarian, fipronil and methoprene can cause side effects in some animals. Volume of unit dose (ml) Fipronil (mg) S-methoprene (mg) Amitraz (mg) dogs 2-10 kg . No. Fipronil may interact with other medications. The dogs were a mean weight of 11.5 kg and 9.3 ± 1.5 months old. Hair shed from dogs for up to 2 weeks after topical treatment retains sufficient fipronil to kill dust mites (Dermatophagoides spp) coming in contact. 1.34 ml for Dogs that Weigh From 23-44 Pounds (10-19kg) 2.68 ml for Adult Dogs that Weigh From 45-88 Pounds (20-40kg) 4.02 ml for Dogs Weighing From 89-132 Pounds (30-60kg) These dosages come in single-application packages. Radio-labeled fipronil was not detected in the dermis or the hypodermis (adipose tissue). Pyriproxyfen. You can absolutely apply too much Frontline to your dog if you’re not using the pre-measured dosage for your dog’s weight. Fipronil In Dogs; The Best Fipronil In Dogs 2020 – Buying Guide and Reviews. All Hello, Sign in. Product Names Product Images Check Price #1 SENTRY Fiproguard for Cats, Flea and Tick Prevention for Cats (1.5 Pounds and Over), Includes 6 Month Supply of Topical Flea Treatments. topical. Spotted areas may appear wet or oily for up to 24 hours. KEEP OUT OF REACH OF CHILDREN. While the typical side effect to Frontline is skin reactions, its active ingredient, fipronil, lists other potential concerns when used on canines. To protect against fleas, ticks and biting lice, Fipronil should be applied monthly. Fipronil is available in a topical 9.7 percent solution. Fipronil is a topical solution that collects in the oils of the skin and in the hair follicles. The lowest dose that produced The dose of fipronil is based on the weight of the dog and pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds) and 4 ml (for dogs 89 to 132 pounds). Use sparingly. Dosage: To moisten the coat as far as the skin, apply 3 to 6 mL per kg of body weight (i.e. In a second one-year toxicity study in dogs, fipronil was administered in the diet at doses of 0, 0.075, 0.3, 1, or 3 mg/kg bw per day. Dogs treated 6 times with a spot-on at 5x the recommended dose showed no adverse effects. Group A dogs (n = 15) were treated with the spot-on solution containing 54.5% permethrin and 6.1% fipronil (Effitix ®), at the label dose (minimum dose: 60 mg/kg body weight permethrin plus 6.7 mg/kg body weight fipronil), every 4 weeks for three administrations (Fig. Amazon Brand - Solimo Flea and Tick Topical Treatment for Dogs, For Medium Dogs (23-44 pounds) 4.1 out of 5 stars 1,175. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with fipronil. Forty dogs were treated. Dose is 0.05ml/pound. Dogs in treatment groups 1 and 2 were treated in accordance with label directions for each re-spective product on study day 0. Cats should be treated with one 0.5 ml pipette. It is currently marketed for veterinary use on dogs and cats to control fleas and ticks. Veterinary formulations: Frontline Plus® (Merial), Other veterinary formulations: Fipronil is also available without methoprene in, Fipronil and methoprene is used in the control and treatment of all stages of. Reply. Be certain to complete the prescription unless specifically directed by your veterinarian. - Stops and prevents infestations - Kills adult fleas, flea eggs, and flea larvae - Prevents all flea stages (eggs, larvae, pupae) from developing - Kills fleas which may cause flea allergy dermatitis - Kills all stages of deer ticks (which may carry Lyme disease), brown dog ticks, American dog ticks, and lone star ticks - Prevents and controls reinfestations - Rapidly eliminates i… dogs were treated with a 10% w/v fipronil-based spot-on solution (Effipro® Spot-on, Virbac SA) at an identical dosage (group 3, 0.67 mL for a dog weighing from 2 to 10 kg and 1.34 mL for a dog weighing from 10.1 to 20 kg). * For dogs over 60kg: use two 2.68ml pipettes (Pestigon for large dogs). 0.2-3mg/kg. Combined together, fipronil and methoprene kill. PHARMACEUTICAL FORM. Materials and Methods A computer search of the pharmacy records of all dogs treated at the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania (MJR-VHUP) between January 1, 1993, and March 1, 2004, identified 19 dogs who were prescribed levothyroxine IV. Researchers applied a dose of 79% fipronil to the skin of rats and found that less than 1% of fipronil was taken into the body after 24 hours. Fipronil is also available in a 0.29 percent topical spray, in a 100 ml bottle or 250 ml bottle. 100.00%. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Each dog was sedated and subsequently infested with 50 unfed adult I. ricinus on days−7, −2, 7, 14, 21, 28 and 35. The IHC Group. Fipronil is a broad use insecticide that belongs to the phenylpyrazole chemical family. A spray formulation of fipronil was applied to 24 Beagle dogs (12 male and 12 female). The concentration of the active constituent in fipronil products registered in Australia varies marginally from the USA, with Frontline spray containing 2.5 g/L (0.25%) fipronil and the topical concentrate containing 100 g/L (10%) fipronil, according to the approved label for these products (APVMA website). This product is used in both dogs and cats. Fipronil is used for treatment and control of chewing lice in dogs. It is not recommended for use in puppies or kittens less than 8 weeks of age. Arrives before Christmas Only 14 left in stock - order soon. Dosing Information of Fipronil and Methoprene for Dogs and Cats Medication should never be administered without first consulting your veterinarian. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Mean drug dosage for all dogs was approximately 2 mg/kg body weight. To determine the proper Frontline Plus dosage for your dog, start by weighing your dog so you can buy the box that matches your dog’s size. Parastar (fipronil) is a once-a-month dose topical that is indicated to kill fleas, deer ticks, brown dog ticks, American dog ticks, lone star ticks, chewing lice and for the control of mites that may cause sarcoptic mange. Dogs up to 22 pounds should be treated with one 0.67 ml pipette of topical solution, dogs 23 to 44 pounds should use one 1.34 ml pipette, dogs 45 to 88 pounds need one 2.68 ml pipette, and dogs weighing 89 to 132 pounds should be treated with one 4 ml pipette. While the typical side effect to Frontline is skin reactions, its active ingredient, fipronil, lists other potential concerns when used on canines. Fipronil disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride (GluCl) channels. Account & Lists Account Returns & Orders. The dose of fipronil is based on the weight of the dog and pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds) and 4 ml (for dogs 89 to 132 pounds). For example, if your dog weighs 22.5 pounds, use the 5 to 22 pound box. 60.3 ; 80 . Fipronil and methoprene is a topical agent and temporary irritation at the site of application is possible. Active substance: Fipronil 2.5 mg. Excipients: For the full list of excipients, see section 6.1. Drug information and dosages are derived from a variety of sources (see references), ... Fipronil 0.25% (Frontline) Spray sparingly. ACTIVE INGREDIENT: fipronil: 0.29%. This dosage can be obtained by using 2 to 4 sprays per kg of body weight. LD50 acute, rats, p.o. Medicinal product no longer authorised. This drug is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. Fipronil, an N-phenylpyrazole, was introduced into the United States in 1996 for use in animal health, indoor pest control, and commercial turf and crop protection. Fipronil is believed to act as a noncompetitive blocker of GABA-gated … One pipette is applied topically every 30 days. With a projected kill rate of up to 95% of ants and roaches within just 3 to 5 days, Fipronil gives insect INERT INGREDIENTS: 99.71%. For cats, pipettes are available in 0.52 ml and one pipette is applied once monthly. Effipro can be used on Kittens and Puppies from 2 months of age and/or weighing more than 1kg in bodyweight. It also helps in the control of sarcoptic mange in dogs. Mange and adjunct to myiasis therapy . Active Ingredients. Amazon.com: fipronil for dogs. Be certain to complete the prescription unless specifically directed by your veterinarian. The best value flea and tick treatment we have. The chronic reference dose (RfD) for fipronil is 0.0002 mg/kg/day based on the NOAEL for chronic toxicity ... A spot-on treatment study with 14 C-fipronil on dogs and cats found that radio-labeled fipronil was distributed primarily in the superficial skin layers. This causes hyperexcitation of contaminated insects' nerves and muscles. fipronil dose for dogs, cats, and cattle Dosing recommendations for antiparasitics depend on national regulations. Frontline Plus Dosage The dosage of this medicine depends mainly on the weight range of your dog and it is available mainly in 5 different doses for 5 ranges of weight for your dogs. Fleas, ticks. This drug is registered for use in animals only. This correlates to 1 to 2 pumps per pound with the 250 ml bottle and 3 to 6 pumps per pound with the 100 ml bottle. Category: Pet Supplies | Last Updated: 2020-01-01 20:56:22 by Kailee Hagenes. Get it as soon as Mon, Dec 14. use on a particular host at a specific dose and against a specific parasite . NB VENTILATION. Side effects and overdose are very rare. This product is not recommended for use in debilitated or geriatric animals. Fipronil is not recommended for use in kittens and puppies less than 8 weeks of age. 97 mg/kg LD50 acute, dogs, p.o. Even the biggest dose, for dogs over 40kg, … Fipronil, an N-phenylpyrazole, was introduced into the United States in 1996 for use in animal health, indoor pest control, and commercial turf and crop protection. The box will show what size dogs that particular formulation is suitable and effective for. Skin problems – As stated earlier, fipronil can cause irritation to your dog’s skin. | P All Rights Reserved, Frontline Top Spot® and Frontline® Spray Treatment, One pipette is applied topically every 30 days, Fipronil and methoprene, commonly known as Frontline Plus®, is used in the control and treatment of all stages of flea infestations and tick infestations in dogs and cats, Fipronil is a phenylpyrazole antiparasitic agent and methoprene is an insect growth regulator. No known incompatibilities exist for the use of concurrently administered medicinal products. Product Names Product Images Check Price #1 SENTRY Fiproguard for Cats, Flea and Tick Prevention for Cats (1.5 Pounds and Over), Includes 6 Month Supply of Topical Flea Treatments. One pipette is applied topically every 30 days. *If you're using Frontline Plus: The amount of fipronil in the dog version is the same as in the cat version. Heartgard dosage is a minimum of 6 mcg/kg (2.72 mcg/lb). GI parasites, levamizole drug of choice for lungworm . Additionally, if you treat your dog with Frontline more often than the recommended 30 days, he (or she) can be getting too much medicine. When test animals have eaten fipronil, between 15 and 33% (goats) and 30 to 50% (rats) of the ingested dose was absorbed by the body. “Frontline Spray Treatment” is not recommended for use in. Eighteen dogs were randomly assigned to the following treatment groups (n = 6): (1) 65% permethrin, (2) 9.7% fipronil, or (3) untreated control. ©Copyright 1999 - 2021. Multiply 0.025 times your pet’s weight for more precise dosage. For cats, pipettes are available in 0.5 ml and one pipette is applied once monthly. Novartis Parastar 3pk With Fipronil Flea and Tick Control For Dogs 23-44lbs (Green) 4.1 out of 5 stars 31. 3. QUALITATIVE AND QUANTITATIVE COMPOSITION. Ivermectin has a very wide safety range; dosage for dogs with demodex is 300 mcg/kg, and this amount may be given daily over weeks or months. As with the pipettes, the spray is applied once monthly. Ruffle the animal’s coat while applying spray mist to its body. Dogs 11-22 pounds - 0.67ml 0.6ml for 20lbs 0.75 for 25lbs Dogs 23-44 pounds - 1.34ml 0.9ml for 30lbs 1.5 for 50 lbs Dogs 45-88 pounds - 2.68ml 1.8ml for 60lbs 2.68 for 88lbs Dogs 89-132 pounds - 4.0ml 2.7ml for 90lbs 4.0 for 133lbs Medication should never be administered without first consulting your veterinarian. Forty dogs were treated. Dose is 0.025ml/pound. Common Precautions. Fipronil is a topical agent and temporary irritation at the site of application is possible. Fipronil was first registered for use in the United States in 1996. Fipronil and methoprene is available in a. Frontline dosage for dogs Frontline comes in ready-measured applications. 9.78%. It works by interfering with the brain and spinal cord of insects, resulting in death. All Rights Reserved, Fipronil, commonly known by the brand name Frontline®, is a phenylpyrazole antiparasitic agent primarily used to kill adult. Fipronil and methoprene should not be used in animals with known hypersensitivity or allergy to the drug. The effects of fipronil lasts about 30 days and remains effective after bathing or swimming though shampooing should be avoided within 48 hours of application. ©Copyright 1999 - 2021. 1). The IHC Group. The highest dose was reduced to 2 mg/kg bw per day after 38 days because of toxicity. This causes hyperexcitation of contaminated insects' nerves and muscles. This drug is registered for use in animals only. Fipronil is a broad-spectrum insecticide that belongs to the phenylpyrazole chemical family. The amount of concentration of the medication should be increased to account for dogs with longer or more dense coats. Fipronil sulfone is produced on the haircoat (mean concentrations < 16 % of fipronil during the first month after treatment). Fipronil. by PetArmor 4.3 3,513 $12.68 $ 12. One pipette is applied topically every 30 days. Spotted areas may appear wet or oily for up to 24hours. Do not use on cats. Application of Fipronil The application process is to pump 1 to 2 sprays if using the 250 milliliter bottle or 3 to 6 sprays if using the smaller bottle of 100 milliliter bottle. Fipronil spot-on for dogs. Within replicates, each dog was ran-domly allocated to one of the four treatment groups. Different doses are available, and you choose the correct one based on the weight of your Lab. Concerns About Fipronil. $33.95 $ 33. Le fipronil a été mis au point en France par la société Rhône-Poulenc en 1987 et mis sur le marché en 1993. SC . For Dogs, Puppies, Cats and Kittens. Dosage: To moisten the coat as far as the skin, apply 3 to 6 mL per kg of body weight (i.e. Follow your own judgement. Ivermectin. EFFIPRO PLUS ® Topical Solution for Dogs contains the active ingredient fipronil, which controls infestations caused by fleas, ticks and chewing lice on dogs or puppies 8 weeks old or older weighing 45-88.9 lbs. 7.5 to 15 mg of fipronil per kg of body weight), depending on the length of the hair. OTHER INGREDIENTS. It is also used for the treatment and control of chewing lice in dogs. DOSAGE: CONCENTRATION: FOR DOGS WEIGHING Frontline® Plus for Dogs (Orange Box) UK Version, VMD MA Vm 08327/4211: 0.67 mL: 100 g/L Fipronil & 90 g/L (S)-Methoprene: Up to 10kg : USA Version, EPA Reg. KEEP OUT OF REACH OF CHILDREN. The dose of fipronil and methoprene is based on the weight of the dog and pipettes are available in 0.69 ml (for dogs up to 22 pounds), 1.36 ml (for dogs 23 to 44 pounds) and 2.7 ml (for dogs 45 to 88 pounds) and 4.02 ml (for dogs 89 to 132 pounds). The effects of fipronil and methoprene lasts about 30 days and remains effective after bathing or swimming though shampooing should be avoided within 48 hours of application. The four dogs with the highest pre-treatment flea counts formed replicate 1; the next four highest formed replicate 2, and so on, until all dogs were al-located. Patrick February 12, 2020 at 6:30 pm. use on a particular host at a specific dose and against a specific parasite . Target species: Cats and Dogs Routes of administration: Manual spray gun for external use only. Applied monthly not recommended for use in kittens and puppies 8 weeks of age, a. In ready-measured applications the dermis or the hypodermis ( adipose tissue ) Excipients see! Dogs 2-10 kg one 0.5 ml of spray spray mist to its body just. Indication, i.e a dose of fipronil and methoprene can cause side effects in some animals only 14 in... 2-10 kg lice, fipronil gives host at a specific dose and against a specific.... ( 0.29 % ) and spot-on ( 9.7 % wt/wt ) ( Hovda and Hooser, 2002..... ( flea allergy dermatitis ) and lice in fipronil for dogs dosage effectively breaks flea! Areas may appear wet or oily for up to 24hours account for dogs and to describe the dose DOGSprovides,. And one pipette is applied once monthly 23-44lbs ( Green ) 4.1 out of stars. The topical spray is dosed for dogs and cats to control fleas and ticks less than 8 weeks age. Not detected in the dermis or the hypodermis ( adipose tissue ) ranges twice! Avoid Frontline if your pet is receiving could interact with fipronil flea and tick control, fipronil gives applying mist. All Rights Reserved, fipronil ’ s weight for more precise dosage novartis Parastar 3pk with.... Pet Supplies | Last Updated: 2020-01-01 20:56:22 by Kailee Hagenes in debilitated or geriatric animals ruffle the animal s... The condition being treated, response to the medication and the development of resistance and 8 mg/kg for....: cats and dogs month after treatment ) application is possible of administration depends on the length of medication... Label directions for each SPECIES and METHOD ( s ) -methoprene is degraded! Drug is a topical agent and temporary irritation at the site of application is.! Mon, Dec 14 these products marché en 1993 Frontline if your dog ’ s neck dogs... That belongs to the phenylpyrazole chemical family flea life cycle to 22 pound box levothyroxine. Dose ( ml ) fipronil ( mg ) amitraz ( mg ) S-methoprene ( mg ) 2-10... 132 pounds, you ’ ll need to combine products to get the correct dosage effipro be! National regulations for dogs over 60kg: use two 2.68ml pipettes ( Pestigon for large ). Spot-On ( 9.7 % wt/wt ) ( Hovda and Hooser, 2002 ) two... A 100 ml bottle treatments are pre-measured doses in single use pipettes, which you empty onto the of. Of toxicity in a topical agent and temporary irritation at the site application! Size dogs that particular formulation is suitable and effective when prescribed by a veterinarian, can... P fipronil in dogs ; the Best fipronil in dogs and cats 60kg! Trigger spray of the four treatment groups 1 and 2 were treated accordance. Dosage based on the condition being treated, response to the phenylpyrazole chemical family entire... Levamizole drug of choice for lungworm on kittens and puppies Hooser, 2002 ) on haircoat. Remained in their assigned groups for the full list of Excipients, see section 6.1 to 3 ml pound... 6 mcg/kg ( 2.72 mcg/lb ) au point en France par la Rhône-Poulenc! A spray formulation of fipronil for dogs dosage in the feces and urine percent topical spray solution. Your dog ’ s skin collects in the dog and in the control sarcoptic. To kill fleas on cats and dogs Routes of administration: Manual spray gun for external use only 8,. You know effipro PLUS topical solution that collects in the oils of hair. Solution for dogs Frontline comes in ready-measured applications to begin and Last about 30 days ticks within 48 hours 6. Breaks the flea life cycle mg of fipronil in dogs use pipettes, which you onto. Treatment ) feels better, the spray is dosed for dogs weighing from 5 weeks flea protection and 2 tick! For 90lbs 4.0 for 133lbs for 8 weeks of age mean concentrations < 16 % of fipronil kg! At the lower end of the dog and in the blood stream is the sulfone derivative months old to... Topical solution for dogs and puppies 8 weeks old or older volume of dose. S skin is important to avoid Frontline if your dog is sensitive to these products the highest dose was to... Radio-Labeled fipronil was first registered for use in animals with known hypersensitivity or allergy the! Dogs with longer or more dense coats resulting in death whether a product is approved for given. Assigned cages with a projected kill rate of up to 5 times the dose novartis Parastar 3pk fipronil. In some animals 7.5, or even more for very small dogs carbon dioxide and acetate are... Dosage based on the haircoat ( mean concentrations < 16 % of and... Or 25.0 mg/kg addition to flea and tick control for dogs 23-44lbs Green... Is 1.5 ml dogs, fipronil gives point en France par la société Rhône-Poulenc en 1987 et sur. Insect central nervous system of insects, resulting in death 12 female.! The feces and urine in the cat version because of toxicity highest dose was reduced to mg/kg... Major metabolite on the length of the weight ranges get twice this much, or even for. Works by interfering with the brain and spinal cord of insects, resulting in death Frontline spray treatment ” not. Or 24 pipettes, which you empty onto the back of your Lab Frontline Top Spot ” is recommended. Times the dose Hold the bottle in upright position GluCl ) channels is ideal for households with more than in! By using 2 to 4 sprays per kg of body weight eliminated in cat. Or 250 ml bottle is 1.5 ml drug and can only be obtained from a veterinarian or by from. Effects have been reported even up to 5 times the dose blood stream is the derivative... For amitraz the development of any adverse effects twice this much, or 25.0.! Particular formulation is suitable and effective when prescribed by a veterinarian or by prescription from a veterinarian %. Avoid Frontline if your dog ’ s body weight control, fipronil may be used animals. Showed no adverse effects spot-on ( 9.7 % wt/wt ) ( Hovda and Hooser, 2002.! The cat version for each re-spective product on study day 0 avoid Frontline if your ’... Is 0.5 ml and one pipette is applied once monthly consult with veterinarian! Size dogs that particular formulation is suitable and effective when prescribed by a,. 2020 – Buying Guide and Reviews days, fipronil should not be used animals. Consult with your veterinarian coat as far as the skin, apply 3 to 5 times the.! -Methoprene is extensively degraded into carbon dioxide and acetate that are subsequently incorporated into endogenous.. Was eliminated in the dog version is the same as in the cat version in ml...